Endocrine Abstracts

Context and Objectives: The prognosis of medullary thyroid carcinoma (MTC), derived from parafollicular C-cells, depends on the completeness of the first surgical treatment. The C-cells produce calcitonin, a peptid hormone that is used as biochemical and immunohistochemical tumor marker. The aim of study was to evaluate an individualized approach to patients with C-cell disease, i.e. MTC and C-cell hyperplasia (CCH), using the intraoperative calcitonin testing-assisted surgica...

Parathyroid carcinoma (PTCa) is an uncommon cause of primary hyperparathyroidism (PHP), statistically representing <1–2% of all cases of PHP. Early resection of the primary tumor is the only curative treatment, however this is frequently incomplete. As a consequence, recurrence of PTCa presenting as locally invasive tumor and/or metastatic process is not rare. Morbidity and mortality are generally caused by the effects of unremitting hypercalcemia rather than tumor gr...

Introduction: A possible involvement of proteasomes in the pathogenesis of type II diabetes mellitus has been recently reported. Therefore, association of polymorphism of proteosomal genes with type II diabetes mellitus is of particular interest. In this study, molecular markers of the proteasomal alpha subunit 6 gene PSMA6 and its adjacent genomic sites have been analyzed.The goal of this study was to characterize polymorphisms of the HSMS801, HSMS702, ...